1-(4-Pyridinyl)-4-piperidinecarbonyl chloride → HCID 18174563, compound

HRID 395832Notes

Reaction equation

HRID 395832 reaction equation
C(O[O:9][C:10]1[CH:11]=[C:12]([NH:16][C:17](=[O:25])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[NH2:24])[CH:13]=[CH:14][CH:15]=1)C1C=CC=CC=1.[N:26]1[CH:31]=[CH:30][C:29]([N:32]2[CH2:40][CH2:39][CH:35]([C:36](Cl)=[O:37])[CH2:34][CH2:33]2)=[CH:28][CH:27]=1>>[N:26]1[CH:31]=[CH:30][C:29]([N:32]2[CH2:40][CH2:39][CH:35]([C:36]([NH:24][C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[C:17]([NH:16][C:12]3[CH:13]=[CH:14][CH:15]=[C:10]([O:9][CH2:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[CH:11]=3)=[O:25])=[O:37])[CH2:34][CH2:33]2)=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 111837001-(4-Pyridinyl)-4-piperidinecarbonyl chlorideHCID 18174464HCID 18174464, compound

Product 1

HCID 18174563HCID 18174563, compoundYield 164.8%

Procedure

Using the procedure described in Example 138, N-(3-benzyloxyoxyphenyl)-2-aminobenzamide (0.97 mmol) and N-(4-pyridyl)isonipecotoyl chloride (1.9 mmol), yielded 405 mg (82%) of the title compound.

Sources & evidence

ORD record
ord-835f30ae029e4d959606134bc41a1c8c
Source dataset
uspto-grants-2003_08
Patent number
US06605626B2

Reaction notes

Loading…