HCID 1203873, compound → HCID 18174517, compound

HRID 395834Notes

Reaction equation

HRID 395834 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:17])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[NH2:16].[N:18]1[CH:23]=[CH:22][C:21]([N:24]2[CH2:32][CH2:31][CH:27]([C:28]([Cl:30])=[O:29])[CH2:26][CH2:25]2)=[CH:20][CH:19]=1>>[ClH:30].[N:18]1[CH:23]=[CH:22][C:21]([N:24]2[CH2:25][CH2:26][CH:27]([C:28]([NH:16][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[C:9]([NH:8][C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[F:1])=[O:17])=[O:29])[CH2:31][CH2:32]2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 1203873HCID 1203873, compoundHCID 111837001-(4-Pyridinyl)-4-piperidinecarbonyl chloride

Product 1

HCID 18174517HCID 18174517, compoundYield 35%

Procedure

Using the procedure described in Example 138, N-(2-fluorophenyl)-2-aminobenzamide (0.89 mmol) and N-(4-pyridyl)isonipecotoyl chloride (2.23 mmol), purifying with RPHPLC Method A, yielded 141 mg (35%) of the title compound.

Workup

  1. custompurifying with RPHPLC Method A

Sources & evidence

ORD record
ord-b13070d28950421ba7702da8e3d5e591
Source dataset
uspto-grants-2003_08
Patent number
US06605626B2

Reaction notes

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