HCID 6481530, compound → HCID 18174570, compound

HRID 395840Notes

Reaction equation

HRID 395840 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:8][C:9](=[O:17])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[NH2:16])[CH:5]=[CH:6][CH:7]=1.[N:18]1[CH:23]=[CH:22][C:21]([N:24]2[CH2:32][CH2:31][CH:27]([C:28]([Cl:30])=[O:29])[CH2:26][CH2:25]2)=[CH:20][CH:19]=1>>[ClH:30].[N:18]1[CH:23]=[CH:22][C:21]([N:24]2[CH2:25][CH2:26][CH:27]([C:28]([NH:16][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[C:9]([NH:8][C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=3)=[O:17])=[O:29])[CH2:31][CH2:32]2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 6481530HCID 6481530, compoundHCID 111837001-(4-Pyridinyl)-4-piperidinecarbonyl chloride

Product 1

HCID 18174570HCID 18174570, compoundYield 68%

Procedure

Using the procedure described in Example-138, N-(3-fluorophenyl)-2-aminobenzamide (1.3 mmol) and N-(4-pyridyl)isonipecotoyl chloride (2.6 mmol), purifying with RPHPLC Method D, yielded 402 mg (68%) of the title compound.

Workup

  1. custompurifying with RPHPLC Method D

Sources & evidence

ORD record
ord-e700d7d030144fe79b5370926ff410d4
Source dataset
uspto-grants-2003_08
Patent number
US06605626B2

Reaction notes

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