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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 395847Generated: October 29, 2026

4-(Dimethylamino)benzoic acid → 4-(Dimethylamino)benzoyl chloride

https://huagongshe.com/reaction/395847

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Dimethylamino)benzoic acidHCID 12092—
ReactantThionyl ChlorideHCID 24386—
SolventDichloromethaneHCID 6344—
Product4-(Dimethylamino)benzoyl chlorideHCID 4400782—

Reaction Steps

A solution of 4-(dimethylamino)benzoic acid and thionyl chloride in methylene chloride was refluxed 4 h. Volatile solvents were removed in vacuo to yield 1.10 g of 4-(dimethylamino)benzoyl chloride. This material was used in subsequent reactions without purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06605626B2
Source datasetuspto-grants-2003_08
ORD IDord-f7f72ca29f2d4710a4a640c3928897f0
Source noteuspto-grants-2003_08