Toluene → HCID 69361977, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-amino-4-(N-tert-butoxycarbonylamino)nitrobenzene (2.1 g, 8.3 mmol) in toluene (50 mL) was treated with phosgene (1.93M in toluene, 12.9 mL, 24.9 mmol) and the mixture-was heated at 50° C. After 2 h, the mixture was concentrated, the residue was dissolved in CH2Cl2 and treated with triethylamine (2.31 mL, 16.6 mmol) and 1-(4-pyridyl)piperidine-4-methanol (1.59 g, 8.29 mmol). After 16 h, the mixture was concentrated and the residue purified by chromatography (9:1 CH2Cl2:MeOH) affording 1.78 g (46%) of the title compound.

Provenance & Evidence