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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 395865Generated: October 26, 2026

Lipoic acid → N-(4-{[amino(2-thienyl)methylidene]amino}phenyl)-2-(1,2-dithiolan-3-yl)acetamide

https://huagongshe.com/reaction/395865

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLipoic acidHCID 6112—
Reactant2-(1,2-Dithiolan-3-YL)acetic acidHCID 10866681—
ReactantTrisnorlipoic acidHCID 29923430—
ReactantHCID 178479319HCID 178479319—
ProductN-(4-{[amino(2-thienyl)methylidene]amino}phenyl)-2-(1,2-dithiolan-3-yl)acetamideHCID 10406425—

Reaction Steps

The experimental protocol used is the same as that described for compound 1, with trisnorlipoic acid [or 2-(1,2-dithiolan-3-yl)acetic acid] (prepared according to Tetrahedron Letters, (1997), 38, 33, 5785) replacing lipoic acid. Yellow foam.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06605637B1
Source datasetuspto-grants-2003_08
ORD IDord-126596f24f87442ea37f8ea43d8fd9de
Source noteuspto-grants-2003_08