Methyl morpholine oxide → HCID 18173035, compound

Participants

Reaction Steps

8-(5-Methylene-tricyclo[2.2.1.02,6]hept-3-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione (284 mg) was taken in acetone:water (1:1, 5 ml) at 0° C. OsO4 (2 ml) was added and the mixture was stirred for 15 min. N-Methylmorpholine-N-oxide (120 mg) was added and the mixture was stirred at room temperature overnight. The next day the reaction mixture was quenched with NaHSO3 solution, extracted with ethyl acetate (3×25 ml). Combined organic layer was washed with water, brine and dried over Na2SO4. After concentration the crude product was purified on a silica column. (ES+ 375)

Provenance & Evidence