HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → HCID 18173110, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 5,6-Diamino-2,4-dihydroxypyrimidine monohydrochloride | HCID 76725 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 18173119 | HCID 18173119 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 18173110 | HCID 18173110 | — |
Reaction Steps
3-Oxo-bicyclo[3.2.1]octane-8-carboxylic acid (205 mg) from step 1 was coupled to diaminouracil HCl (395 mg) using EDC (287 mg) in CH2Cl2 in the presence of DIEA (490 mg) and cyclized in iPrOH (50 ml), 1N KOH (10 ml) at reflux overnight. The crude product was purified on silica column. Yield (210 mg). Mass (ES+ 359).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06605600B1 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-5a6264c1e95f470290a9c7bc483c64df |
| Source note | uspto-grants-2003_08 |