Potassium Hydroxide → HCID 18173122, compound

HRID 395883Notes

Reaction equation

HRID 395883 reaction equation
C([O:3][C:4](=[O:32])[CH2:5][NH:6][CH:7]1[CH:12]2[CH2:13][CH2:14][CH:8]1[CH2:9][CH:10]([C:15]1[NH:23][C:22]3[C:21](=[O:24])[N:20]([CH2:25][CH2:26][CH3:27])[C:19](=[O:28])[N:18]([CH2:29][CH2:30][CH3:31])[C:17]=3[N:16]=1)[CH2:11]2)C.[OH-].[K+]>CO.C1COCC1>[O:28]=[C:19]1[N:18]([CH2:29][CH2:30][CH3:31])[C:17]2[N:16]=[C:15]([CH:10]3[CH2:11][CH:12]4[CH:7]([NH:6][CH2:5][C:4]([OH:32])=[O:3])[CH:8]([CH2:14][CH2:13]4)[CH2:9]3)[NH:23][C:22]=2[C:21](=[O:24])[N:20]1[CH2:25][CH2:26][CH3:27]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 60032951HCID 60032951, compound

Product 1

HCID 18173122HCID 18173122, compound

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

[3-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[3.2.1]oct-8-ylamino]-acetic acid ethyl ester (Example 40a) was hydrolyzed using 1N KOH in MeOH/THF. Mass (ES+418)

Sources & evidence

ORD record
ord-f3ab6a1b6f414d06950662a398051c47
Source dataset
uspto-grants-2003_08
Patent number
US06605600B1

Reaction notes

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