Formaldehyde → HCID 18767636, compound

Participants

Reaction Steps

A solution of 1,3-dipropyl-3,9-dihydro-purine-2,6-dione (446 mg, 1.89 mmol), 37% aqueous formaldehyde (1.2 eq, 2.26 mmol, 0.190 ml) and pyrrolidine (1.2 eq, 2.26 mmol, 161 mg) in EtOH (25 ml) was heated at relux for 36 h. The cool reaction mixture was concentrated in vacuo to give a solid that was dried in vacuo for 24 h (598 mg, 99%). 1H NMR (300 MHz, CDCl3); d 0.94 (coincident t, 6H), 1.64 (m, 2H), 1.75 (m, 4H), 1.78 (m, 2H, partially-obscured), 2.69 (m, 2H), 4.00 (m, 4H), 5.30 (s, 2H), 7.59 (s, 1H); MS: 320 (MH+).

Provenance & Evidence