HCID 9922919, compound → HCID 69862217, compound

Participants

Reaction Steps

A suspension consisting of 50.0 g of rac-1,4-dibenzyl-3-oxo-piperidine hydrochloride (0.158 mol), 0.50 l of water and 10.0 g of 5% palladium on charcoal (Pd/C) was stirred under a hydrogen atmosphere until 3.5 l of gas had been consumed (1 h). Then the Pd/C was filtered off and rinsed with water, the filtrate was evaporated and the residue taken up in isopropanol. The crystallization started spontaneously and was completed at 5° C. over night. The precipitate was filtered off, the filter cake was rinsed with cold isopropanol and dried to constant weight (0.2 mbar, room temperature, 2 h) to afford 30 g of rac-4-benzyl-pyperidine-3-one hydrochloride as light yellow crystals. Elemental analysis:

Provenance & Evidence