HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → (S)-2-(tert-Butyldimethylsilyloxy)-g-butyrolactone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | 3-Hydroxybutyrolactone, (3S)- | HCID 7269389 | — |
| Product | (S)-2-(tert-Butyldimethylsilyloxy)-g-butyrolactone | HCID 10965951 | — |
Reaction Steps
3.92 g (38.4 mmol) of (S)-3-hydroxybutyrolactone with 5.23 g (2 equivalents, 76.8 mmol) of imidazole are introduced at 0° C. into 50 ml of absolute DMF. 7.53 g (1.3 equivalents, 49.92 mmol) of TBSCl is now slowly added and stirred for 2.5 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06605726B1 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-6a09d1ba34d54481a03948cc134cebb3 |
| Source note | uspto-grants-2003_08 |