Benzene → HCID 69978805, compound

Participants

Reaction Steps

Tri-n-butylphosphane (38 ml, 0.156 mol) was added to a solution of 4-chloromethyl-2-methylthiazole (23 g, 0.156 mol) in anhydrous benzene (200 ml) under argon, and the solution was heated to boiling for 8 hours. Then, it was concentrated by evaporation in a vacuum, the residue was dried for 30 more minutes at 0.01 Torr, and the phosphonium salt was brought to crystallization by trituration with dry diethyl ether. 53 g (97%) of the title compound was obtained as colorless, hygroscopic crystals.

Provenance & Evidence