HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → 4-(4-{2-[(2S)-2-Hydroxy-3-(4-hydroxy-phenoxy)-propylamino]-ethyl}-phenylamino)-piperidine-1-carboxylic Acid 4-fluoro-benzylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane | HCID 12045564 | — |
| Reactant | 4-[4-(2-Aminoethyl)anilino]-N-(4-fluorobenzyl)-1-piperidinecarboxamide formate | HCID 69986724 | — |
| Product | 4-(4-{2-[(2S)-2-Hydroxy-3-(4-hydroxy-phenoxy)-propylamino]-ethyl}-phenylamino)-piperidine-1-carboxylic Acid 4-fluoro-benzylamide | HCID 10280301 | 40.4% |
Reaction Steps
4-[4-(2-Aminoethyl)anilino]-N-(4-fluorobenzyl)-1-piperidinecarboxamide formate (0.77 g, 1.85 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.671 g, 1.66 mmol) according to Procedure G to give the title compound (0.53 g, 0.67 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06605618B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-d8fd4515ff714aaeb4bee9cc9bdcc0c3 |
| Source note | uspto-grants-2003_08 |