HCID 69987465, compound → HCID 10140889, compound

HRID 395989Notes

Reaction equation

C(O)=O.[NH2:4][CH2:5][CH2:6][C:7]1[CH:26]=[CH:25][C:10]([NH:11][CH:12]2[CH2:17][CH2:16][N:15]([C:18]([N:20]([CH2:23][CH3:24])[CH2:21][CH3:22])=[O:19])[CH2:14][CH2:13]2)=[CH:9][CH:8]=1.[SiH4].C([Si]([O:45][C:46]1[CH:51]=[CH:50][C:49]([O:52][CH2:53][CH:54]2[CH2:56][O:55]2)=[CH:48][CH:47]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>>[CH2:21]([N:20]([CH2:23][CH3:24])[C:18]([N:15]1[CH2:16][CH2:17][CH:12]([NH:11][C:10]2[CH:9]=[CH:8][C:7]([CH2:6][CH2:5][NH:4][CH2:56][C@H:54]([OH:55])[CH2:53][O:52][C:49]3[CH:50]=[CH:51][C:46]([OH:45])=[CH:47][CH:48]=3)=[CH:26][CH:25]=2)[CH2:13][CH2:14]1)=[O:19])[CH3:22]

Participants

Reactant 2

HCID 69987465HCID 69987465, compound

HCID 131723495HCID 131723495, compound

Product 1

HCID 10140889HCID 10140889, compoundYield 24.2%

Procedure

4-[4-(2-Aminoethyl)anilino]-N,N-diethyl-1-piperidinecarboxamide formate (0.37 g, 1.01 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane silane (0.367 g, 0.909 mmol) according to Procedure G to give the title compound (eluant: 20:1 chloroform-methanol) (0.159 g, 0.22 mmol).

Sources & evidence

ORD record: ord-9dccb4d29c6b4ee0bf73dab646169428
Source dataset: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06605618B2

Reaction notes

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