Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 10202842, compound

HRID 395995Notes

Reaction equation

HRID 395995 reaction equation
C(O)=O.[NH2:4][CH2:5][CH2:6][C:7]1[CH:22]=[CH:21][C:10]([NH:11][CH:12]2[CH2:17][CH2:16][N:15]([C:18]([NH2:20])=[O:19])[CH2:14][CH2:13]2)=[CH:9][CH:8]=1.C([Si]([O:40][C:41]1[CH:46]=[CH:45][C:44]([O:47][CH2:48][CH:49]2[CH2:51][O:50]2)=[CH:43][CH:42]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>>[OH:50][C@H:49]([CH2:48][O:47][C:44]1[CH:45]=[CH:46][C:41]([OH:40])=[CH:42][CH:43]=1)[CH2:51][NH:4][CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]([NH:11][CH:12]2[CH2:17][CH2:16][N:15]([C:18]([NH2:20])=[O:19])[CH2:14][CH2:13]2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 69985895HCID 69985895, compound

Product 1

HCID 10202842HCID 10202842, compoundYield 12.9%

Procedure

4-[4-(2-Aminoethyl)anilino]-1-piperidinecarboxamide formate (0.76 g, 2.37 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.817 g, 2.02 mmol) according to Procedure G to give the title compound (eluant: 20:1 chloroform-methanol) (0.175 g, 0.26 mmol).

Sources & evidence

ORD record
ord-aecee17a5746463fa483a30032683c81
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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