HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-N-(4-(Oxiran-2-ylmethoxy)phenyl)methanesulfonamide → 4-(4-{2-[(2S)-2-Hydroxy-3-(4-methanesulfonylamino-phenoxy)-propylamino]-ethyl}-phenylamino)-piperidine-1-carboxylic Acid Octylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-N-(4-(Oxiran-2-ylmethoxy)phenyl)methanesulfonamide | HCID 11322479 | — |
| Reactant | 4-[4-(2-Aminoethyl)anilino]-N-octyl-1-piperidinecarboxamide | HCID 18173662 | — |
| Solvent | Chloroform methanol | HCID 21584188 | — |
| Product | 4-(4-{2-[(2S)-2-Hydroxy-3-(4-methanesulfonylamino-phenoxy)-propylamino]-ethyl}-phenylamino)-piperidine-1-carboxylic Acid Octylamide | HCID 10189248 | 12.1% |
Reaction Steps
4-[4-(2-Aminoethyl)anilino]-N-octyl-1-piperidinecarboxamide (0.245 g, 0.58 mmol) was reacted with N-{4-[(2S)oxiranylmethoxy]phenyl}methanesulfonamide (0.13 g, 0.53 mmol) according to Procedure G (eluant: 20:1 chloroform-methanol) to give the title compound (0.04 g, 0.064 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06605618B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-227ae8718c594e1da2511698c2342d5f |
| Source note | uspto-grants-2003_08 |