HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 396Generated: October 27, 2026
Morpholine → Dimethyl 5-morpholinoisophthalate
https://huagongshe.com/reaction/396
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 1,3-Benzenedicarboxylic acid, 5-bromo-, 1,3-dimethyl ester | HCID 103954 | — |
| Reagent | Cesium carbonate | HCID 10796 | — |
| Catalyst | Binap, (A+-)- | HCID 634876 | — |
| Catalyst | Palladium (II) acetate | HCID 4144353 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Dimethyl 5-morpholinoisophthalate | HCID 57496003 | 78.22% |
Reaction Steps
To a solution of dimethyl 5-bromoisophthalate (10 g, 36.62 mmol) in toluene (100 mL) where BINAP (2.5 g, 4.01 mmol), morpholine (4.4 g, 50.50 mmol), CESIUM CARBONATE (18 g, 55.25 mmol) and PALLADIUM(II) ACETATE (0.9 g, 4.01 mmol) added. The solution was heated to reflux under inert atm for 14h. The silvent was filtered and the filtrate was concentrated. The residue was purified by column chropmatography (Hep:EA) 1:1 to give dimethyl 5-morpholinoisophthalate (8.00 g, 78 %)
Provenance & Evidence
| Source dataset | 750 AstraZeneca ELN dataset |
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| ORD ID | ord-ff0eb93bbb4b45cdb3807c4588dd206f |
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| Source note | 750 AstraZeneca ELN dataset |
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