HCID 69986890, compound → HCID 10145557, compound

HRID 396007Notes

Reaction equation

HRID 396007 reaction equation
C([Si](C1C=CC=CC=1)(C1C=CC=CC=1)[O:6][C:7]1[CH:50]=[CH:49][C:10]([O:11][CH2:12][C@@H:13]([OH:48])[CH2:14][NH:15][CH2:16][CH2:17][C:18]2[CH:47]=[CH:46][C:21]([NH:22][CH:23]3[CH2:28][CH2:27][N:26]([C:29]([NH:31][CH2:32][CH:33]([C:40]4[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=4)[C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)=[O:30])[CH2:25][CH2:24]3)=[CH:20][CH:19]=2)=[CH:9][CH:8]=1)(C)(C)C>C(Cl)(Cl)Cl.CO>[C:34]1([CH:33]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[CH2:32][NH:31][C:29]([N:26]2[CH2:27][CH2:28][CH:23]([NH:22][C:21]3[CH:46]=[CH:47][C:18]([CH2:17][CH2:16][NH:15][CH2:14][C@H:13]([OH:48])[CH2:12][O:11][C:10]4[CH:49]=[CH:50][C:7]([OH:6])=[CH:8][CH:9]=4)=[CH:19][CH:20]=3)[CH2:24][CH2:25]2)=[O:30])[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1

Participants

3

Reactant 1

HCID 69986890HCID 69986890, compound

Product 1

HCID 10145557HCID 10145557, compoundYield 63.6%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

4-[4-(2-{[(2S)-3-(4-{[tert-Butyl (diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-N-(2,2-diphenylethyl)-1-piperidinecarboxamide (0.20 g, 0.236 mmol) was reacted according to Procedure H (eluant: 5:1 chloroform-methanol containing 1% ammonium hydroxide) to give the title compound (0.095 g, 0.15 mmol)

Sources & evidence

ORD record
ord-86349ec594f0465fb945bd243c53f860
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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