Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 86584583, compound

HRID 396022Notes

Reaction equation

HRID 396022 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([CH:13]2[CH2:18][CH2:17][N:16]([C:19]([NH:21][CH2:22][C:23]3([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[CH2:27][CH2:26][CH2:25][CH2:24]3)=[O:20])[CH2:15][CH2:14]2)(=[O:12])=[O:11])=[CH:6][CH:5]=1.C([Si]([O:51][C:52]1[CH:57]=[CH:56][C:55]([O:58][CH2:59][CH:60]2[CH2:62][O:61]2)=[CH:54][CH:53]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>>[C:28]1([C:23]2([CH2:22][NH:21][C:19]([N:16]3[CH2:15][CH2:14][CH:13]([S:10]([C:7]4[CH:6]=[CH:5][C:4]([CH2:3][CH2:2][NH:1][CH2:62][C@H:60]([OH:61])[CH2:59][O:58][C:55]5[CH:56]=[CH:57][C:52]([OH:51])=[CH:53][CH:54]=5)=[CH:9][CH:8]=4)(=[O:12])=[O:11])[CH2:18][CH2:17]3)=[O:20])[CH2:27][CH2:26][CH2:25][CH2:24]2)[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 18173539HCID 18173539, compound

Product 1

HCID 86584583HCID 86584583, compoundYield 33.1%

Procedure

4-{[4-(2-Aminoethyl)phenyl]sulfonyl}-N-[(1-phenylcyclopentyl)methyl]-1-piperidinecarboxamide (0.570 g, 1.20 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane (0.417 g, 1.03 mmol) according to Procedure G to give the title compound (eluant: 20:1 chloroform-methanol) (0.298 g, 0.341 mmol).

Sources & evidence

ORD record
ord-dfafdaa424df4f7ca641ed3a88d42564
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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