HCID 12044202, compound → HCID 10121537, compound

HRID 396024Notes

Reaction equation

[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([CH:13]2[CH2:18][CH2:17][N:16]([C:19]([NH:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])=[O:20])[CH2:15][CH2:14]2)(=[O:12])=[O:11])=[CH:6][CH:5]=1.C([Si](C(C)C)(C(C)C)[O:34][C:35]1[CH:40]=[CH:39][C:38]([O:41][CH2:42][C@@H:43]2[CH2:45][O:44]2)=[CH:37][C:36]=1[CH3:46])(C)C>>[CH2:22]([NH:21][C:19]([N:16]1[CH2:17][CH2:18][CH:13]([S:10]([C:7]2[CH:6]=[CH:5][C:4]([CH2:3][CH2:2][NH:1][CH2:45][C@H:43]([OH:44])[CH2:42][O:41][C:38]3[CH:39]=[CH:40][C:35]([OH:34])=[C:36]([CH3:46])[CH:37]=3)=[CH:9][CH:8]=2)(=[O:12])=[O:11])[CH2:14][CH2:15]1)=[O:20])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29]

Participants

Reactant 2

HCID 12044202HCID 12044202, compound

HCID 18173851HCID 18173851, compound

Product 1

HCID 10121537HCID 10121537, compoundYield 16.8%

Procedure

4-{[4-(2-Aminoethyl)phenyl]sulfonyl}-N-octyl-1-piperidinecarboxamide (1.38 g, 3.258 mmol) was reacted with triisopropyl{2-methyl-4-[(2S)oxiranylmethoxy]phenoxy}silane (1.04 g, 3.095 mmol) according to Procedure G to give the title compound (eluant: 20:1 chloroform:methanol) (0.395 g, 0.520 mmol).

Sources & evidence

ORD record: ord-dcd86c2dbe0747329a80ce933cde91dc
Source dataset: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06605618B2

Reaction notes

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