Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 10282615, compound

HRID 396032Notes

Reaction equation

HRID 396032 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:33]=[CH:32][C:7]([NH:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]([NH:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]3[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[C:24]([O:30][CH3:31])[CH:23]=3)=[O:16])[CH2:11][CH2:10]2)=[CH:6][CH:5]=1.C([Si]([O:51][C:52]1[CH:57]=[CH:56][C:55]([O:58][CH2:59][CH:60]2[CH2:62][O:61]2)=[CH:54][CH:53]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>C(Cl)(Cl)Cl.CO>[CH3:31][O:30][C:24]1[CH:23]=[C:22]([CH2:21][CH2:20][CH2:19][CH2:18][NH:17][C:15]([N:12]2[CH2:13][CH2:14][CH:9]([NH:8][C:7]3[CH:32]=[CH:33][C:4]([CH2:3][CH2:2][NH:1][CH2:62][CH:60]([OH:61])[CH2:59][O:58][C:55]4[CH:56]=[CH:57][C:52]([OH:51])=[CH:53][CH:54]=4)=[CH:5][CH:6]=3)[CH2:10][CH2:11]2)=[O:16])[CH:27]=[CH:26][C:25]=1[O:28][CH3:29]

Participants

4

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 18173710HCID 18173710, compound

Product 1

HCID 10282615HCID 10282615, compoundYield 52.8%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

4-[4-(2-Aminoethyl)anilino]-N-[4-(3,4-dimethoxyphenyl)butyl]-1-piperidinecarboxamide (0.79 g, 1.42 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.36 g, 0.89 mmol) according to Procedure G (eluant: 20:1 chloroform-methanol) to give the title compound (0.40 g, 0.47 mmol).

Sources & evidence

ORD record
ord-5ef8b1f44e824eaab2c2fb8264a99605
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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