HuagongsheHuagongshe Chemistry Print Report · For research reference only
t-Butyl{2-fluoro-4-[(2s)oxiranylmethoxy]phenoxy}diphenylsilane → 4-(4-[2-[(2S)-3-(3-Fluoro-4-hydroxy-phenoxy)-2-hydroxy-propylamino]-ethyl]-phenylamino)-piperidine-1-carboxylic acid octylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | t-Butyl{2-fluoro-4-[(2s)oxiranylmethoxy]phenoxy}diphenylsilane | HCID 23381349 | — |
| Reactant | 4-[4-(2-Aminoethyl)anilino]-N-octyl-1-piperidinecarboxamide formate | HCID 69987252 | — |
| Solvent | Chloroform methanol | HCID 21584188 | — |
| Product | 4-(4-[2-[(2S)-3-(3-Fluoro-4-hydroxy-phenoxy)-2-hydroxy-propylamino]-ethyl]-phenylamino)-piperidine-1-carboxylic acid octylamide | HCID 10231259 | 31.1% |
Reaction Steps
4-[4-(2-Aminoethyl)anilino]-N-octyl-1-piperidinecarboxamide formate (0.376 g, 0.87 mmol) was reacted with tert-butyl{2-fluoro-4-[(2S)oxiranylmethoxy]phenoxy}diphenylsilane (0.368 g, 0.87 mmol) according to Procedure G (eluant: 20:1 chloroform-methanol) to give the title compound (0.228 g, 0.271 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06605618B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-6e9618c287544242a011e076bb6a68e7 |
| Source note | uspto-grants-2003_08 |