HRID396041

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CS(=O)(=O)Nc1cc(OC[C@@H]2CO2)ccc1OCc1ccccc1

HCID53819537

未命名化合物

结构：CCCCCCCCNC(=O)N1CCC(Nc2ccc(CCN)cc2)CC1.O=CO

HCID69987252

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCNC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)c(NS(C)(=O)=O)c3)cc2)CC1

HCID10168241

未命名化合物

收率 19%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21584188

Chloroform methanol

C2H5Cl3O

PROCEDURE

实验过程

4-[4-(2-Aminoethyl)anilino]-N-octyl-1-piperidinecarboxamide formate (0.516 g, 1.2 mmol) was reacted with N-{2-(benzyloxy)-5-[(2S)oxiranylmethoxy]phenyl) methanesulfonamide (prepared according to patent WO9604233) (0.38 g, 1.09 mmol) according to Procedure G (eluant: 20:1 chloroform-methanol) to give the title compound (0.15 g, 0.207 mmol).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a50f49cebeb945ad80586ab721fa0c57
来源数据集: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06605618B2
来源说明: uspto-grants-2003_08

反应 SMILES

C(O)=O.[NH2:4][CH2:5][CH2:6][C:7]1[CH:30]=[CH:29][C:10]([NH:11][CH:12]2[CH2:17][CH2:16][N:15]([C:18]([NH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[O:19])[CH2:14][CH2:13]2)=[CH:9][CH:8]=1.C([O:38][C:39]1[CH:44]=[CH:43][C:42]([O:45][CH2:46][C@@H:47]2[CH2:49][O:48]2)=[CH:41][C:40]=1[NH:50][S:51]([CH3:54])(=[O:53])=[O:52])C1C=CC=CC=1>C(Cl)(Cl)Cl.CO>[CH2:21]([NH:20][C:18]([N:15]1[CH2:16][CH2:17][CH:12]([NH:11][C:10]2[CH:9]=[CH:8][C:7]([CH2:6][CH2:5][NH:4][CH2:49][C@H:47]([OH:48])[CH2:46][O:45][C:42]3[CH:43]=[CH:44][C:39]([OH:38])=[C:40]([NH:50][S:51]([CH3:54])(=[O:53])=[O:52])[CH:41]=3)=[CH:30][CH:29]=2)[CH2:13][CH2:14]1)=[O:19])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]