Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 70002120, compound

HRID 396043Notes

Reaction equation

HRID 396043 reaction equation
C(O)=O.[CH:4]1([CH2:10][CH2:11][CH2:12][NH:13][C:14]([N:16]2[CH2:21][CH2:20][CH:19]([NH:22][C:23]3[CH:38]=[CH:37][C:26]([CH2:27][CH2:28][NH:29]C(=O)OC(C)(C)C)=[CH:25][CH:24]=3)[CH2:18][CH2:17]2)=[O:15])[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1.C([Si]([O:56][C:57]1[CH:62]=[CH:61][C:60]([O:63][CH2:64][CH:65]2[CH2:67][O:66]2)=[CH:59][CH:58]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>C(Cl)(Cl)Cl.CO>[CH:4]1([CH2:10][CH2:11][CH2:12][NH:13][C:14]([N:16]2[CH2:21][CH2:20][CH:19]([NH:22][C:23]3[CH:38]=[CH:37][C:26]([CH2:27][CH2:28][NH:29][CH2:67][C@H:65]([OH:66])[CH2:64][O:63][C:60]4[CH:61]=[CH:62][C:57]([OH:56])=[CH:58][CH:59]=4)=[CH:25][CH:24]=3)[CH2:18][CH2:17]2)=[O:15])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]1

Participants

4

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 86584584HCID 86584584, compound

Product 1

HCID 70002120HCID 70002120, compoundYield 36%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

tert-Butyl 4-[(1-{[(3-cyclohexylpropyl)amino]carbonyl}-4-piperidinyl)amino]phenethylcarbamate formate (0.35 g, 0.809 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.327 g, 0.809 mmol) according to Procedure G (eluant: 20:1 going to 10:1 chloroform-methanol) to give the title compound (0.23 g, 0.291 mmol).

Sources & evidence

ORD record
ord-2106faf2bb904e71a6b3ded7afbbb2de
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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