HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-(Benzyloxy)-5-[(2S)oxiranylmethoxy]-3,4-dihydro-2(1H)-quinolinone → 4-(4-[2-[(2S)-2-Hydroxy-3-(8-hydroxy-2-oxo-1,2,3,4-tetrahydro-quinolin-5-yloxy)-propylamino]-ethyl}-phenylamino)-piperidine-1-carboxylicacid octylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-(Benzyloxy)-5-[(2S)oxiranylmethoxy]-3,4-dihydro-2(1H)-quinolinone | HCID 23381344 | — |
| Reactant | 4-[4-(2-Aminoethyl)anilino]-N-octyl-1-piperidinecarboxamide formate | HCID 69987252 | — |
| Solvent | Chloroform methanol | HCID 21584188 | — |
| Product | 4-(4-[2-[(2S)-2-Hydroxy-3-(8-hydroxy-2-oxo-1,2,3,4-tetrahydro-quinolin-5-yloxy)-propylamino]-ethyl}-phenylamino)-piperidine-1-carboxylicacid octylamide | HCID 10232593 | 27.1% |
Reaction Steps
4-[4-(2-Aminoethyl)anilino]-N-octyl-1-piperidinecarboxamide formate (0.431 g, 1.0 mmol) was reacted with 8-(benzyloxy)-5-[(2S)oxiranylmethoxy]-3,4-dihydro-2(1H)-quinolinone (0.325 g, 1.0 mmol) according to Procedure G (eluant: 20:1 chloroform-methanol) to give the title compound (0.19 g, 0.271 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06605618B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-5bb4c5d454d64d348c8c8a3ed85cf84b |
| Source note | uspto-grants-2003_08 |