HRID396046

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCCCCCCNC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(OCc4ccccc4)c4c3CCC(=O)N4)cc2)CC1

HCID69985748

未命名化合物

HCID178418361

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCNC(=O)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)c4c3CCC(=O)N4)cc2)CC1

HCID10232593

未命名化合物

收率 36%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

4-(4-{2-[((2S)-3-{[8-(Benzyloxy)-2-oxo-1,2,3,4-tetrahydro-5-quinolinyl]oxy}-2-hydroxypropyl)amino]ethyl}anilino)-N-octyl-1-piperidinecarboxamide (0.16 g, 0.228 mmol) was dissolved in ethanol and 10% palladium on carbon (0.07 g) added. The solution was shaken in a Parr apparatus at 50 psi hydrogen atmosphere for 4 hours, filtered through a Celite pad and the solvent removed in vacuo. The residue was purified by flash silica gel chromatography on silica gel Merck-60 to yield the title compound (0.05 g, 0.082 mmol).

WORKUP

后处理

filtrationfiltered through a Celite pad
customthe solvent removed in vacuo
customThe residue was purified by flash silica gel chromatography on silica gel Merck-60

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1f3a437c86124c3092220d399201c8d4
来源数据集: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06605618B2
来源说明: uspto-grants-2003_08

反应 SMILES

C([O:8][C:9]1[CH:10]=[CH:11][C:12]([O:20][CH2:21][C@@H:22]([OH:51])[CH2:23][NH:24][CH2:25][CH2:26][C:27]2[CH:50]=[CH:49][C:30]([NH:31][CH:32]3[CH2:37][CH2:36][N:35]([C:38]([NH:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH3:48])=[O:39])[CH2:34][CH2:33]3)=[CH:29][CH:28]=2)=[C:13]2[C:18]=1[NH:17][C:16](=[O:19])[CH2:15][CH2:14]2)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[CH2:41]([NH:40][C:38]([N:35]1[CH2:36][CH2:37][CH:32]([NH:31][C:30]2[CH:49]=[CH:50][C:27]([CH2:26][CH2:25][NH:24][CH2:23][C@H:22]([OH:51])[CH2:21][O:20][C:12]3[CH:11]=[CH:10][C:9]([OH:8])=[C:18]4[C:13]=3[CH2:14][CH2:15][C:16](=[O:19])[NH:17]4)=[CH:28][CH:29]=2)[CH2:33][CH2:34]1)=[O:39])[CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH3:48]