Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 10185894, compound

HRID 396047Notes

Reaction equation

HRID 396047 reaction equation
C(O)=O.[NH2:4][CH2:5][CH2:6][C:7]1[CH:28]=[CH:27][C:10]([NH:11][CH:12]2[CH2:17][CH2:16][N:15]([C:18]([NH:20][CH2:21][CH:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)=[O:19])[CH2:14][CH2:13]2)=[CH:9][CH:8]=1.C([Si]([O:46][C:47]1[CH:52]=[CH:51][C:50]([O:53][CH2:54][CH:55]2[CH2:57][O:56]2)=[CH:49][CH:48]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>C(Cl)(Cl)Cl.CO>[CH:22]1([CH2:21][NH:20][C:18]([N:15]2[CH2:16][CH2:17][CH:12]([NH:11][C:10]3[CH:9]=[CH:8][C:7]([CH2:6][CH2:5][NH:4][CH2:57][C@H:55]([OH:56])[CH2:54][O:53][C:50]4[CH:51]=[CH:52][C:47]([OH:46])=[CH:48][CH:49]=4)=[CH:28][CH:27]=3)[CH2:13][CH2:14]2)=[O:19])[CH2:23][CH2:24][CH2:25][CH2:26]1

Participants

4

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 69987856HCID 69987856, compound

Product 1

HCID 10185894HCID 10185894, compoundYield 39%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

4-[4-(2-Aminoethyl)anilino]-N-(cyclopentylmethyl)-1-piperidinecarboxamide formate (0.38 g, 0.818 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.32 g, 0.792 mmol) according to Procedure G (eluant: 20:1 going to 10:1 chloroform-methanol) to give the title compound (0.24 g, 0.309 mmol).

Sources & evidence

ORD record
ord-f2794f73c24b48c69585094f76de9d3a
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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