Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 86587234, compound

HRID 396049Notes

Reaction equation

HRID 396049 reaction equation
C(O)=O.[NH2:4][CH2:5][CH2:6][C:7]1[CH:43]=[CH:42][C:10]([NH:11][CH:12]2[CH2:17][CH2:16][N:15]([C:18]([NH:20][CH2:21][CH2:22][C:23]3[CH:28]=[CH:27][C:26]([O:29][CH2:30][CH2:31][CH2:32][O:33][C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)=[CH:25][C:24]=3[O:40][CH3:41])=[O:19])[CH2:14][CH2:13]2)=[CH:9][CH:8]=1.C([Si]([O:61][C:62]1[CH:67]=[CH:66][C:65]([O:68][CH2:69][CH:70]2[CH2:72][O:71]2)=[CH:64][CH:63]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>C(Cl)(Cl)Cl.CO>[CH3:41][O:40][C:24]1[CH:25]=[C:26]([O:29][CH2:30][CH2:31][CH2:32][O:33][C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)[CH:27]=[CH:28][C:23]=1[CH2:22][CH2:21][NH:20][C:18]([N:15]1[CH2:16][CH2:17][CH:12]([NH:11][C:10]2[CH:9]=[CH:8][C:7]([CH2:6][CH2:5][NH:4][CH2:72][C@H:70]([OH:71])[CH2:69][O:68][C:65]3[CH:66]=[CH:67][C:62]([OH:61])=[CH:63][CH:64]=3)=[CH:43][CH:42]=2)[CH2:13][CH2:14]1)=[O:19]

Participants

4

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 69987323HCID 69987323, compound

Product 1

HCID 86587234HCID 86587234, compoundYield 39.6%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

4-[4-(2-Aminoethyl)anilino]-N-[2-methoxy-4-(3-phenoxypropoxy)phenethyl]-1-piperidinecarboxamide formate (0.426 g, 0.718 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.29 g, 0.718 mmol) according to Procedure G (eluant: 20:1 chloroform-methanol) to give the title compound (0.27 g, 0.284 mmol).

Sources & evidence

ORD record
ord-737174da9bef4405b40d3a0a4f7bec02
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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