HCID 86587235, compound → HCID 86587234, compound

HRID 396050Notes

Reaction equation

HRID 396050 reaction equation
C([Si](C1C=CC=CC=1)(C1C=CC=CC=1)[O:6][C:7]1[CH:57]=[CH:56][C:10]([O:11][CH2:12][C@@H:13]([OH:55])[CH2:14][NH:15][CH2:16][CH2:17][C:18]2[CH:54]=[CH:53][C:21]([NH:22][CH:23]3[CH2:28][CH2:27][N:26]([C:29]([NH:31][CH2:32][CH2:33][C:34]4[CH:39]=[CH:38][C:37]([O:40][CH2:41][CH2:42][CH2:43][O:44][C:45]5[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=5)=[CH:36][C:35]=4[O:51][CH3:52])=[O:30])[CH2:25][CH2:24]3)=[CH:20][CH:19]=2)=[CH:9][CH:8]=1)(C)(C)C>C(Cl)(Cl)Cl.CO>[CH3:52][O:51][C:35]1[CH:36]=[C:37]([O:40][CH2:41][CH2:42][CH2:43][O:44][C:45]2[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=2)[CH:38]=[CH:39][C:34]=1[CH2:33][CH2:32][NH:31][C:29]([N:26]1[CH2:27][CH2:28][CH:23]([NH:22][C:21]2[CH:20]=[CH:19][C:18]([CH2:17][CH2:16][NH:15][CH2:14][C@H:13]([OH:55])[CH2:12][O:11][C:10]3[CH:56]=[CH:57][C:7]([OH:6])=[CH:8][CH:9]=3)=[CH:54][CH:53]=2)[CH2:24][CH2:25]1)=[O:30]

Participants

3

Reactant 1

HCID 86587235HCID 86587235, compound

Product 1

HCID 86587234HCID 86587234, compoundYield 59.2%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

4-[4-(2-{[(2S)-3-(4-{[tert-Butyl (diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]-amino}ethyl)anilino]-N-[2-methoxy-4-(3-phenoxypropoxy)phenethyl]-1-piperidinecarboxamide (0.25 g, 0.26 mmol) was reacted according to Procedure H (eluant: 10:1 chloroform-methanol) to give the title compound (0.11 g, 0.154 mmol).

Sources & evidence

ORD record
ord-c76e3bcee17540bba2f8baace52b4d8f
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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