HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxy-propyl]amino]ethoxy)anilino]-N-octyl-1-piperidinecarboxamide → 4-(4-[2-[(2S)-2-Hydroxy-3-(4-hydroxy-phenoxy)-propylamino]-ethoxy}-phenylamino)-piperidine-1-carboxylic acid octylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxy-propyl]amino]ethoxy)anilino]-N-octyl-1-piperidinecarboxamide | HCID 69985502 | — |
| Solvent | Chloroform methanol | HCID 21584188 | — |
| Product | 4-(4-[2-[(2S)-2-Hydroxy-3-(4-hydroxy-phenoxy)-propylamino]-ethoxy}-phenylamino)-piperidine-1-carboxylic acid octylamide | HCID 10231207 | 54.6% |
Reaction Steps
4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxy-propyl]amino]ethoxy)anilino]-N-octyl-1-piperidinecarboxamide (0.30 g, 0.377 mmol) was reacted according to Procedure H (eluant: 10:1 chloroform-methanol) to give the title compound (0.115 g, 0.206 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06605618B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-4a43836e245b4da4999688db063a7cd2 |
| Source note | uspto-grants-2003_08 |