Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 10187468, compound

HRID 396056Notes

Reaction equation

HRID 396056 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:28]=[CH:27][C:7]([NH:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]([NH:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[CH:20]=3)=[O:16])[CH2:11][CH2:10]2)=[CH:6][CH:5]=1.C([Si]([O:46][C:47]1[CH:52]=[CH:51][C:50]([O:53][CH2:54][CH:55]2[CH2:57][O:56]2)=[CH:49][CH:48]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>>[CH3:26][O:25][C:21]1[CH:20]=[C:19]([CH:24]=[CH:23][CH:22]=1)[CH2:18][NH:17][C:15]([N:12]1[CH2:11][CH2:10][CH:9]([NH:8][C:7]2[CH:6]=[CH:5][C:4]([CH2:3][CH2:2][NH:1][CH2:57][C@H:55]([OH:56])[CH2:54][O:53][C:50]3[CH:51]=[CH:52][C:47]([OH:46])=[CH:48][CH:49]=3)=[CH:28][CH:27]=2)[CH2:14][CH2:13]1)=[O:16]

Participants

3

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 18173925HCID 18173925, compound

Product 1

HCID 10187468HCID 10187468, compound

Procedure

4-[4-(2-Aminoethyl)anilino]-N-(3-methoxybenzyl)-1-piperidinecarboxamide (0.73 g, 2.0 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane according to Procedure G to give the title compound (0.53 g, 0.67 mmol).

Sources & evidence

ORD record
ord-79230c1e1bb143f1b2063504246592ce
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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