Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 86584586, compound

HRID 396059Notes

Reaction equation

HRID 396059 reaction equation
C(O)=O.[NH2:4][CH2:5][CH2:6][C:7]1[CH:35]=[CH:34][C:10]([NH:11][CH:12]2[CH2:17][CH2:16][N:15]([C:18]([NH:20][CH2:21][CH2:22][C:23]([N:25]([CH3:33])[C:26]3[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=3)=[O:24])=[O:19])[CH2:14][CH2:13]2)=[CH:9][CH:8]=1.C([Si]([O:53][C:54]1[CH:59]=[CH:58][C:57]([O:60][CH2:61][CH:62]2[CH2:64][O:63]2)=[CH:56][CH:55]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>>[Cl:32][C:29]1[CH:28]=[CH:27][C:26]([N:25]([CH3:33])[C:23]([CH2:22][CH2:21][NH:20][C:18]([N:15]2[CH2:14][CH2:13][CH:12]([NH:11][C:10]3[CH:9]=[CH:8][C:7]([CH2:6][CH2:5][NH:4][CH2:64][C@H:62]([OH:63])[CH2:61][O:60][C:57]4[CH:58]=[CH:59][C:54]([OH:53])=[CH:55][CH:56]=4)=[CH:35][CH:34]=3)[CH2:17][CH2:16]2)=[O:19])=[O:24])=[CH:31][CH:30]=1

Participants

3

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 69985365HCID 69985365, compound

Product 1

HCID 86584586HCID 86584586, compound

Procedure

4-[4-(2-Aminoethyl)anilino]-N-(3-[4-chloro(methyl)anilino]-3-oxopropyl)-1-piperidinecarboxamide formate (0.78 g, 1.55 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane according to Procedure G to provide the title compound (0.27 g, 0.3 mmol)

Sources & evidence

ORD record
ord-d447a9ce7a8f43c0b520562168868867
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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