Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 69985614, compound

HRID 396060Notes

Reaction equation

HRID 396060 reaction equation
C(O)=O.[NH2:4][CH2:5][CH2:6][C:7]1[CH:48]=[CH:47][C:10]([NH:11][CH:12]2[CH2:17][CH2:16][N:15]([C:18]([NH:20][CH2:21][C:22]3[CH:27]=[CH:26][C:25]([O:28][Si](C(C)(C)C)(C4C=CC=CC=4)C4C=CC=CC=4)=[CH:24][C:23]=3[F:46])=[O:19])[CH2:14][CH2:13]2)=[CH:9][CH:8]=1.C([Si]([O:66][C:67]1[CH:72]=[CH:71][C:70]([O:73][CH2:74][CH:75]2[CH2:77][O:76]2)=[CH:69][CH:68]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>>[F:46][C:23]1[CH:24]=[C:25]([OH:28])[CH:26]=[CH:27][C:22]=1[CH2:21][NH:20][C:18]([N:15]1[CH2:16][CH2:17][CH:12]([NH:11][C:10]2[CH:47]=[CH:48][C:7]([CH2:6][CH2:5][NH:4][CH2:77][CH:75]([OH:76])[CH2:74][O:73][C:70]3[CH:71]=[CH:72][C:67]([OH:66])=[CH:68][CH:69]=3)=[CH:8][CH:9]=2)[CH2:13][CH2:14]1)=[O:19]

Participants

3

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 69985395HCID 69985395, compound

Product 1

HCID 69985614HCID 69985614, compound

Procedure

4-[4-(2-Aminoethyl)anilino]-N-(4-{[tert-butyl(diphenyl)silyl]oxy}-2-fluorobenzyl)-1-piperidinecarboxamide formate (0.855 g, 1.3 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane according to Procedure G to give the title compound (0.24 g, 0.2 mmol).

Sources & evidence

ORD record
ord-fb5c2880f31745608b705580c3623d9c
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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