Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 10121901, compound

HRID 396061Notes

Reaction equation

HRID 396061 reaction equation
C(O)=O.[CH3:4][N:5]([CH3:36])[C:6](=[O:35])[O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][NH:15][C:16]([N:18]2[CH2:23][CH2:22][CH:21]([NH:24][C:25]3[CH:30]=[CH:29][C:28]([CH2:31][CH2:32][NH2:33])=[CH:27][CH:26]=3)[CH2:20][CH2:19]2)=[O:17])=[C:10]([F:34])[CH:9]=1.C([Si]([O:54][C:55]1[CH:60]=[CH:59][C:58]([O:61][CH2:62][CH:63]2[CH2:65][O:64]2)=[CH:57][CH:56]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>>[F:34][C:10]1[CH:9]=[C:8]([O:7][C:6](=[O:35])[N:5]([CH3:4])[CH3:36])[CH:13]=[CH:12][C:11]=1[CH2:14][NH:15][C:16]([N:18]1[CH2:19][CH2:20][CH:21]([NH:24][C:25]2[CH:26]=[CH:27][C:28]([CH2:31][CH2:32][NH:33][CH2:65][C@H:63]([OH:64])[CH2:62][O:61][C:58]3[CH:59]=[CH:60][C:55]([OH:54])=[CH:56][CH:57]=3)=[CH:29][CH:30]=2)[CH2:22][CH2:23]1)=[O:17]

Participants

3

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 18173744HCID 18173744, compound

Product 1

HCID 10121901HCID 10121901, compound

Procedure

4-{[({4-[4-(2-Aminoethyl)anilino]-1-piperidinyl}carbonyl)amino]methyl}-3-fluorophenyl dimethylcarbamate formate (0.225 g, 0.6 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane according to Procedure give the title compound (0.125 g, 0.1 mmol).

Sources & evidence

ORD record
ord-9cd9feb10be443e2924b8a55e13d301d
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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