HCID 18173699, compound → HCID 69987048, compound

HRID 396062Notes

Reaction equation

HRID 396062 reaction equation
[F:1][C:2]1[CH:27]=[CH:26][C:5]([CH2:6][NH:7][C:8]([N:10]2[CH2:15][CH2:14][CH:13]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][NH2:25])=[CH:19][CH:18]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.C([Si]([O:45][C:46]1[CH:51]=[CH:50][CH:49]=[C:48]([O:52][CH2:53][C@@H:54]2[CH2:56][O:55]2)[CH:47]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>>[F:1][C:2]1[CH:27]=[CH:26][C:5]([CH2:6][NH:7][C:8]([N:10]2[CH2:11][CH2:12][CH:13]([NH:16][C:17]3[CH:18]=[CH:19][C:20]([CH2:23][CH2:24][NH:25][CH2:56][C@H:54]([OH:55])[CH2:53][O:52][C:48]4[CH:49]=[CH:50][CH:51]=[C:46]([OH:45])[CH:47]=4)=[CH:21][CH:22]=3)[CH2:14][CH2:15]2)=[O:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 18173699HCID 18173699, compoundHCID 23381352HCID 23381352, compound

Product 1

HCID 69987048HCID 69987048, compound

Procedure

4-[4-(2-Amino-ethyl)-phenylamino]-piperidine-1-carboxylic acid 4-fluoro-benzylamide (0.66 g, 1.6 mmol) was reacted tert-butyl{3-[(2S)oxiranylmethoxy]phenoxy}diphenylsilane according to Procedure G to yield the title compound (0.284 g, 0.4 mmol).

Sources & evidence

ORD record
ord-21cac2a1b0cf44369f0788a33a872339
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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