Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 10304359, compound

HRID 396063Notes

Reaction equation

HRID 396063 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:33]=[CH:32][C:7]([NH:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]([NH:17][CH2:18][C:19]3[CH:30]=[CH:29][C:22]([O:23][CH2:24][C:25]([O:27]C)=[O:26])=[CH:21][C:20]=3[F:31])=[O:16])[CH2:11][CH2:10]2)=[CH:6][CH:5]=1.C([Si]([O:51][C:52]1[CH:57]=[CH:56][C:55]([O:58][CH2:59][CH:60]2[CH2:62][O:61]2)=[CH:54][CH:53]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>>[F:31][C:20]1[CH:21]=[C:22]([CH:29]=[CH:30][C:19]=1[CH2:18][NH:17][C:15]([N:12]1[CH2:13][CH2:14][CH:9]([NH:8][C:7]2[CH:6]=[CH:5][C:4]([CH2:3][CH2:2][NH:1][CH2:62][C@H:60]([OH:61])[CH2:59][O:58][C:55]3[CH:56]=[CH:57][C:52]([OH:51])=[CH:53][CH:54]=3)=[CH:33][CH:32]=2)[CH2:10][CH2:11]1)=[O:16])[O:23][CH2:24][C:25]([OH:27])=[O:26]

Participants

3

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 18173690HCID 18173690, compound

Product 1

HCID 10304359HCID 10304359, compoundYield 27.5%

Procedure

Methyl 2-(4-{[({4-[4-(2-aminoethyl)anilino]-1-piperidinyl}carbonyl)amino]methyl}-3-fluorophenoxy)acetate (0.605 g, 1.2 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.477 g, 1.2 mmol) according to Procedure G to furnish the title compound (0.280 g, 0.33 mmol).

Sources & evidence

ORD record
ord-0ef3e9699dd1442db6ee0c2ab1ce89b2
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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