Chloroform methanol → HCID 69987690, compound

HRID 396068Notes

Reaction equation

[Si]([O:18][C:19]1[CH:64]=[CH:63][C:22]([O:23][CH2:24][C@@H:25]([OH:62])[CH2:26][NH:27][CH2:28][CH2:29][C:30]2[CH:61]=[CH:60][C:33]([NH:34][CH:35]3[CH2:40][CH2:39][N:38]([C:41](C4CCCCN4C(NCCCCCCCC)=O)=[O:42])[CH2:37][CH2:36]3)=[CH:32][CH:31]=2)=[CH:21][CH:20]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1.C(Cl)(Cl)Cl.[CH3:69][OH:70]>>[CH2:28]([NH:27][C:69]([N:38]1[CH2:37][CH2:36][CH:35]([C:41]([N:38]2[CH2:37][CH2:36][CH:35]([NH:34][C:33]3[CH:60]=[CH:61][C:30]([CH2:29][CH2:28][NH:27][CH2:26][C@H:25]([OH:62])[CH2:24][O:23][C:22]4[CH:21]=[CH:20][C:19]([OH:18])=[CH:64][CH:63]=4)=[CH:31][CH:32]=3)[CH2:40][CH2:39]2)=[O:42])[CH2:40][CH2:39]1)=[O:70])[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:60][CH3:61]

Participants

Reactant 2

HCID 21584188Chloroform methanol

HCID 131724027HCID 131724027, compound

Product 1

HCID 69987690HCID 69987690, compound

Procedure

4-((4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-1-piperidinylcarbonyl)-N-octyl-1-piperidinecarboxamide (0.160 g, 0.180 mmol) was reacted according to Procedure H (eluant: 5:1 chloroform-methanol) to give the title compound (0.02 g, 0.03 mmol).

Sources & evidence

ORD record: ord-14fabd7744ff4924bf2a5191d3e561ae
Source dataset: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06605618B2

Reaction notes

Loading…