Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 10211427, compound

HRID 396069Notes

Reaction equation

HRID 396069 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:34]=[CH:33][C:7]([NH:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23](CCCCCC)[C:24]([NH2:26])=[O:25])=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[CH:6][CH:5]=1.C([Si]([O:52][C:53]1[CH:58]=[CH:57][C:56]([O:59][CH2:60][CH:61]2[CH2:63][O:62]2)=[CH:55][CH:54]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>>[CH2:2]([NH:26][C:24]([NH:23][C:20]1[CH:21]=[CH:22][C:17]([C:15]([N:12]2[CH2:11][CH2:10][CH:9]([NH:8][C:7]3[CH:33]=[CH:34][C:4]([CH2:3][CH2:2][NH:1][CH2:63][C@H:61]([OH:62])[CH2:60][O:59][C:56]4[CH:57]=[CH:58][C:53]([OH:52])=[CH:54][CH:55]=4)=[CH:5][CH:6]=3)[CH2:14][CH2:13]2)=[O:16])=[CH:18][CH:19]=1)=[O:25])[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

3

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 18173834HCID 18173834, compound

Product 1

HCID 10211427HCID 10211427, compoundYield 61.5%

Procedure

N-[4-({4-[4-(2-Aminoethyl)anilino]-1-piperidinyl)carbonyl)phenyl]-N-hexylurea (0.394 g, 0.846 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.308 g, 0.761 mmol) according to Procedure G to give the title compound (0.232 g, 0.26 mmol).

Sources & evidence

ORD record
ord-1889522b89294161b4d83130d8fd8109
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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