HCID 69987532, compound → HCID 10211427, compound

HRID 396070Notes

Reaction equation

HRID 396070 reaction equation
[Si]([O:18][C:19]1[CH:63]=[CH:62][C:22]([O:23][CH2:24][C@@H:25]([OH:61])[CH2:26][NH:27][CH2:28][CH2:29][C:30]2[CH:60]=[CH:59][C:33]([NH:34][CH:35]3[CH2:40][CH2:39][N:38]([C:41]([C:43]4[CH:48]=[CH:47][C:46]([NH:49][C:50]([NH:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH3:58])=[O:51])=[CH:45][CH:44]=4)=[O:42])[CH2:37][CH2:36]3)=[CH:32][CH:31]=2)=[CH:21][CH:20]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)(Cl)Cl.CO>[CH2:53]([NH:52][C:50]([NH:49][C:46]1[CH:45]=[CH:44][C:43]([C:41]([N:38]2[CH2:37][CH2:36][CH:35]([NH:34][C:33]3[CH:59]=[CH:60][C:30]([CH2:29][CH2:28][NH:27][CH2:26][C@H:25]([OH:61])[CH2:24][O:23][C:22]4[CH:21]=[CH:20][C:19]([OH:18])=[CH:63][CH:62]=4)=[CH:31][CH:32]=3)[CH2:40][CH2:39]2)=[O:42])=[CH:48][CH:47]=1)=[O:51])[CH2:54][CH2:55][CH2:56][CH2:57][CH3:58]

Participants

3

Reactant 1

HCID 69987532HCID 69987532, compound

Product 1

HCID 10211427HCID 10211427, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

N-[4-({4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-1-piperidinyl}carbonyl)phenyl]-N′-hexylurea (0.160 g, 0.180 mmol) was reacted according to Procedure H (eluant: 5:1 chloroform-methanol) to give the title compound (0.06 g, 0.09 mmol).

Sources & evidence

ORD record
ord-40e009f3116f46ffb01ed7e75fcc45e4
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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