HRID396073

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)[Si](Oc1ccc(OC[C@@H](O)CNCCc2ccc(NC3CCN(C(=O)c4cc5cc(Br)ccc5[nH]4)CC3)cc2)cc1)(c1ccccc1)c1ccccc1

HCID69986966

未命名化合物

PRODUCTS

生成物

结构：O=C(c1cc2cc(Br)ccc2[nH]1)N1CCC(Nc2ccc(CCNC[C@H](O)COc3ccc(O)cc3)cc2)CC1

HCID10167753

未命名化合物

收率 35.5%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21584188

Chloroform methanol

C2H5Cl3O

PROCEDURE

实验过程

(5-Bromo-1H-indol-2-yl){4-[4-(2-{[(2S)-3-(4-{[tert-butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-1-piperidinyl}methanone (0.119 g, 0.141 mmol) was reacted according to Procedure H (eluant: 5:1 chloroform-methanol) to give the title compound (0.031 g, 0.05 mmol).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-569b517b88b349e4a1cad5a35b2fc8b8
来源数据集: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06605618B2
来源说明: uspto-grants-2003_08

反应 SMILES

[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([N:13]1[CH2:18][CH2:17][CH:16]([NH:19][C:20]3[CH:25]=[CH:24][C:23]([CH2:26][CH2:27][NH:28][CH2:29][C@H:30]([OH:57])[CH2:31][O:32][C:33]4[CH:38]=[CH:37][C:36]([O:39][Si](C(C)(C)C)(C5C=CC=CC=5)C5C=CC=CC=5)=[CH:35][CH:34]=4)=[CH:22][CH:21]=3)[CH2:15][CH2:14]1)=[O:12])=[CH:5]2>C(Cl)(Cl)Cl.CO>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([N:13]1[CH2:14][CH2:15][CH:16]([NH:19][C:20]3[CH:21]=[CH:22][C:23]([CH2:26][CH2:27][NH:28][CH2:29][C@H:30]([OH:57])[CH2:31][O:32][C:33]4[CH:34]=[CH:35][C:36]([OH:39])=[CH:37][CH:38]=4)=[CH:24][CH:25]=3)[CH2:17][CH2:18]1)=[O:12])=[CH:5]2