Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 69987129, compound

HRID 396081Notes

Reaction equation

HRID 396081 reaction equation
C(O)=O.[NH2:4][CH2:5][CH2:6][C:7]1[CH:36]=[CH:35][C:10]([NH:11][CH:12]2[CH2:17][CH2:16][N:15]([C:18]([C@@H:20]3[CH2:24][CH2:23][CH2:22][N:21]3[S:25]([C:28]3[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=3)(=[O:27])=[O:26])=[O:19])[CH2:14][CH2:13]2)=[CH:9][CH:8]=1.C([Si]([O:54][C:55]1[CH:60]=[CH:59][C:58]([O:61][CH2:62][CH:63]2[CH2:65][O:64]2)=[CH:57][CH:56]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>>[F:34][C:31]1[CH:30]=[CH:29][C:28]([S:25]([N:21]2[CH2:22][CH2:23][CH2:24][C@H:20]2[C:18]([N:15]2[CH2:16][CH2:17][CH:12]([NH:11][C:10]3[CH:35]=[CH:36][C:7]([CH2:6][CH2:5][NH:4][CH2:65][C@H:63]([OH:64])[CH2:62][O:61][C:58]4[CH:59]=[CH:60][C:55]([OH:54])=[CH:56][CH:57]=4)=[CH:8][CH:9]=3)[CH2:13][CH2:14]2)=[O:19])(=[O:26])=[O:27])=[CH:33][CH:32]=1

Participants

3

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 69987161HCID 69987161, compound

Product 1

HCID 69987129HCID 69987129, compoundYield 21.8%

Procedure

{4-[4-(2-Aminoethyl)anilino]-1-piperidinyl}{(2S)-1-[(4-fluorophenyl)sulfonyl]-pyrrolidinyl}methanone formate (0.30 g, 0.574 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.232 g, 0.574 mmol) according to Procedure G to give the title compound (0.11 g, 0.125 mmol).

Sources & evidence

ORD record
ord-4a54c716f1104efbb8e9020978a0bd3b
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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