Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 69986992, compound

HRID 396084Notes

Reaction equation

HRID 396084 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([S:10][CH:11]2[CH2:16][CH2:15][N:14]([C:17]([C:19]3[S:20][CH:21]=[CH:22][C:23]=3[CH3:24])=[O:18])[CH2:13][CH2:12]2)=[CH:6][CH:5]=1.C([Si]([O:42][C:43]1[CH:48]=[CH:47][C:46]([O:49][CH2:50][CH:51]2[CH2:53][O:52]2)=[CH:45][CH:44]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>>[OH:52][C@H:51]([CH2:50][O:49][C:46]1[CH:47]=[CH:48][C:43]([OH:42])=[CH:44][CH:45]=1)[CH2:53][NH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([S:10][CH:11]2[CH2:12][CH2:13][N:14]([C:17]([C:19]3[S:20][CH:21]=[CH:22][C:23]=3[CH3:24])=[O:18])[CH2:15][CH2:16]2)=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 18173553HCID 18173553, compound

Product 1

HCID 69986992HCID 69986992, compoundYield 59.6%

Procedure

(4-{[4-(2-Aminoethyl)phenyl]sulfanyl}-1-piperidinyl)(3-methyl-2-thienyl)methanone (0.57 g, 1.58 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane (0.58 g, 1.44 mmol) according to Procedure G to give the title compound (eluant: 20:1 chloroform-methanol) (0.656 g, 0.858 mmol).

Sources & evidence

ORD record
ord-8b26193159c645da95ab667639c3e991
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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