n-[4-({4-[4-(2-{[(2s)-3-(4-{[Tert-butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-1-piperidinyl}sulfonyl)phenyl]-n'-hexylurea → 1-Hexyl-3-{4-[4-(4-[2-[(2S)-2-hydroxy-3-(4-hydroxy-phenoxy)-propylamino]-ethyl}-phenylamino)-piperidine-1-sulfonyl]-phenyl]-urea

HRID 396086Notes

Reaction equation

HRID 396086 reaction equation
[Si]([O:18][C:19]1[CH:64]=[CH:63][C:22]([O:23][CH2:24][C@@H:25]([OH:62])[CH2:26][NH:27][CH2:28][CH2:29][C:30]2[CH:61]=[CH:60][C:33]([NH:34][CH:35]3[CH2:40][CH2:39][N:38]([S:41]([C:44]4[CH:49]=[CH:48][C:47]([NH:50][C:51]([NH:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH3:59])=[O:52])=[CH:46][CH:45]=4)(=[O:43])=[O:42])[CH2:37][CH2:36]3)=[CH:32][CH:31]=2)=[CH:21][CH:20]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)(Cl)Cl.CO>[CH2:54]([NH:53][C:51]([NH:50][C:47]1[CH:48]=[CH:49][C:44]([S:41]([N:38]2[CH2:37][CH2:36][CH:35]([NH:34][C:33]3[CH:60]=[CH:61][C:30]([CH2:29][CH2:28][NH:27][CH2:26][C@H:25]([OH:62])[CH2:24][O:23][C:22]4[CH:21]=[CH:20][C:19]([OH:18])=[CH:64][CH:63]=4)=[CH:31][CH:32]=3)[CH2:40][CH2:39]2)(=[O:43])=[O:42])=[CH:45][CH:46]=1)=[O:52])[CH2:55][CH2:56][CH2:57][CH2:58][CH3:59]

Participants

3

Reactant 1

HCID 88089230n-[4-({4-[4-(2-{[(2s)-3-(4-{[Tert-butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-1-piperidinyl}sulfonyl)phenyl]-n'-hexylurea

Product 1

HCID 699853941-Hexyl-3-{4-[4-(4-[2-[(2S)-2-hydroxy-3-(4-hydroxy-phenoxy)-propylamino]-ethyl}-phenylamino)-piperidine-1-sulfonyl]-phenyl]-urea

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

N-[4-({4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxy-propyl]amino}ethyl)anilino]-1-piperidinyl}sulfonyl)phenyl]-N′-hexylurea (0.18 g, 0.199 mmol) was reacted according to Procedure H (eluant: 5:1 chloroform-methanol) to give the title compound as the hydrochloride salt (0.1 g, 0.142 mmol).

Sources & evidence

ORD record
ord-bc3c83d3c5b9452887a63ef42a98ef6b
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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