HRID396087

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6932898

未命名化合物

结构：CCCCCCN(C(N)=O)c1ccc(S(=O)(=O)N2CCC(Nc3ccc(CCN)cc3)CC2)cc1.O=CO

HCID69987119

未命名化合物

PRODUCTS

生成物

结构：CCCCCCNC(=O)Nc1ccc(S(=O)(=O)N2CCC(Nc3ccc(CCNC[C@H](O)COc4ccc(F)cc4)cc3)CC2)cc1

HCID69986647

未命名化合物

收率 63.6%

PROCEDURE

实验过程

N-[4-({4-[4-(2-Aminoethyl)anilino]-1-piperidinyl}sulfonyl)phenyl]-N-hexylurea formate (0.20 g 0.365 mmol) was reacted with (2S)-2-[(4-fluorophenoxy)methyl]oxirane (0.061 mL, 0.365 mmol) according to Procedure G to give the title compound (0.078 g, 0.116 mmol).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-47df9504b03b498883b523046f7111b4
来源数据集: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06605618B2
来源说明: uspto-grants-2003_08

反应 SMILES

C(O)=O.[NH2:4][CH2:5][CH2:6][C:7]1[CH:38]=[CH:37][C:10]([NH:11][CH:12]2[CH2:17][CH2:16][N:15]([S:18]([C:21]3[CH:26]=[CH:25][C:24]([N:27](CCCCCC)[C:28]([NH2:30])=[O:29])=[CH:23][CH:22]=3)(=[O:20])=[O:19])[CH2:14][CH2:13]2)=[CH:9][CH:8]=1.[F:39][C:40]1[CH:50]=[CH:49][C:43]([O:44][CH2:45][C@@H:46]2[CH2:48][O:47]2)=[CH:42][CH:41]=1>>[F:39][C:40]1[CH:50]=[CH:49][C:43]([O:44][CH2:45][C@@H:46]([OH:47])[CH2:48][NH:4][CH2:5][CH2:6][C:7]2[CH:38]=[CH:37][C:10]([NH:11][CH:12]3[CH2:17][CH2:16][N:15]([S:18]([C:21]4[CH:22]=[CH:23][C:24]([NH:27][C:28]([NH:30][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])=[O:29])=[CH:25][CH:26]=4)(=[O:19])=[O:20])[CH2:14][CH2:13]3)=[CH:9][CH:8]=2)=[CH:42][CH:41]=1