(2S)-2-[(4-fluorophenoxy)methyl]oxirane → 1-[4-[4-(4-{2-[(2S)-3-(4-Fluoro-phenoxy)-2-hydroxy-propylamino]-ethyl}-phenylamino)-piperidine-1-sulfonyl]-phenyl}-3-hexyl-urea

HRID 396087Notes

Reaction equation

HRID 396087 reaction equation
C(O)=O.[NH2:4][CH2:5][CH2:6][C:7]1[CH:38]=[CH:37][C:10]([NH:11][CH:12]2[CH2:17][CH2:16][N:15]([S:18]([C:21]3[CH:26]=[CH:25][C:24]([N:27](CCCCCC)[C:28]([NH2:30])=[O:29])=[CH:23][CH:22]=3)(=[O:20])=[O:19])[CH2:14][CH2:13]2)=[CH:9][CH:8]=1.[F:39][C:40]1[CH:50]=[CH:49][C:43]([O:44][CH2:45][C@@H:46]2[CH2:48][O:47]2)=[CH:42][CH:41]=1>>[F:39][C:40]1[CH:50]=[CH:49][C:43]([O:44][CH2:45][C@@H:46]([OH:47])[CH2:48][NH:4][CH2:5][CH2:6][C:7]2[CH:38]=[CH:37][C:10]([NH:11][CH:12]3[CH2:17][CH2:16][N:15]([S:18]([C:21]4[CH:22]=[CH:23][C:24]([NH:27][C:28]([NH:30][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])=[O:29])=[CH:25][CH:26]=4)(=[O:19])=[O:20])[CH2:14][CH2:13]3)=[CH:9][CH:8]=2)=[CH:42][CH:41]=1

Participants

3

Reactant 2

HCID 6932898(2S)-2-[(4-fluorophenoxy)methyl]oxiraneHCID 69987119N-[4-({4-[4-(2-Aminoethyl)anilino]-1-piperidinyl}sulfonyl)phenyl]-N-hexylurea formate

Product 1

HCID 699866471-[4-[4-(4-{2-[(2S)-3-(4-Fluoro-phenoxy)-2-hydroxy-propylamino]-ethyl}-phenylamino)-piperidine-1-sulfonyl]-phenyl}-3-hexyl-ureaYield 63.6%

Procedure

N-[4-({4-[4-(2-Aminoethyl)anilino]-1-piperidinyl}sulfonyl)phenyl]-N-hexylurea formate (0.20 g 0.365 mmol) was reacted with (2S)-2-[(4-fluorophenoxy)methyl]oxirane (0.061 mL, 0.365 mmol) according to Procedure G to give the title compound (0.078 g, 0.116 mmol).

Sources & evidence

ORD record
ord-47df9504b03b498883b523046f7111b4
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

Loading…