Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 69985867, compound

HRID 396092Notes

Reaction equation

HRID 396092 reaction equation
C(O)=O.[C:4]1([C:10]2[N:11]=[C:12]([N:15]3[CH2:20][CH2:19][CH:18]([NH:21][C:22]4[CH:37]=[CH:36][C:25]([CH2:26][CH2:27][NH:28][C:29](=O)OC(C)(C)C)=[CH:24][CH:23]=4)[CH2:17][CH2:16]3)[S:13][CH:14]=2)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C([Si]([O:55][C:56]1[CH:61]=[CH:60][C:59]([O:62][CH2:63][CH:64]2C[O:65]2)=[CH:58][CH:57]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>>[OH:65][C@@H:64]([CH2:29][NH:28][CH2:27][CH2:26][C:25]1[CH:24]=[CH:23][C:22]([NH:21][CH:18]2[CH2:19][CH2:20][N:15]([C:12]3[S:13][CH:14]=[C:10]([C:4]4[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=4)[N:11]=3)[CH2:16][CH2:17]2)=[CH:37][CH:36]=1)[CH2:63][O:62][C:59]1[CH:60]=[CH:61][C:56]([OH:55])=[CH:57][CH:58]=1

Participants

3

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 18425663HCID 18425663, compound

Product 1

HCID 69985867HCID 69985867, compoundYield 30.7%

Procedure

tert-Butyl 4-{[1-(4-phenyl-1,3-thiazol-2-yl)-4-piperidinyl]amino}phenethylcarbamate formate (0.40 g 1.04 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.42 g, 1.04 mmol) according to Procedure G to give the title compound (0.25 g, 0.319 mmol).

Sources & evidence

ORD record
ord-375e219315e2447e9e984dbc9a89187d
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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