HCID 69985877, compound → HCID 69985867, compound

HRID 396093Notes

Reaction equation

HRID 396093 reaction equation
[Si]([O:18][C:19]1[CH:56]=[CH:55][C:22]([O:23][CH2:24][C@@H:25]([OH:54])[CH2:26][NH:27][CH2:28][CH2:29][C:30]2[CH:35]=[CH:34][C:33]([NH:36][CH:37]3[CH2:42][CH2:41][N:40]([C:43]4[S:44][CH:45]=[C:46]([C:48]5[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=5)[N:47]=4)[CH2:39][CH2:38]3)=[CH:32][CH:31]=2)=[CH:21][CH:20]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)(Cl)Cl.CO>[OH:54][C@@H:25]([CH2:26][NH:27][CH2:28][CH2:29][C:30]1[CH:31]=[CH:32][C:33]([NH:36][CH:37]2[CH2:42][CH2:41][N:40]([C:43]3[S:44][CH:45]=[C:46]([C:48]4[CH:49]=[CH:50][CH:51]=[CH:52][CH:53]=4)[N:47]=3)[CH2:39][CH2:38]2)=[CH:34][CH:35]=1)[CH2:24][O:23][C:22]1[CH:55]=[CH:56][C:19]([OH:18])=[CH:20][CH:21]=1

Participants

3

Reactant 1

HCID 69985877HCID 69985877, compound

Product 1

HCID 69985867HCID 69985867, compound

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

(2S)-1-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-3-[(4-{[1-(4-phenyl-1,3-thiazol-2-yl)-4-piperidinyl]amino}phenethyl)amino]-2-propanol (0.25 g, 0.319 mmol) was reacted following general Procedure H (eluant: 5:1 chloroform-methanol) to give the title compound as the hydrochloride salt (0.12 g, 0.22 mmol).

Sources & evidence

ORD record
ord-350d99ebe1ee491c8ef0b6c86aa88406
Source dataset
uspto-grants-2003_08
Patent number
US06605618B2

Reaction notes

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