HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Fmoc-leucine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-(2-methylpropyl)- | HCID 11727923 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Fmoc-leucine | HCID 1549133 | — |
Reaction Steps
FMOC-Leu*-Cl was prepared by dissolving FMOC-N-isobutylglycine (150 mg, 0.42 mmol) in CH2Cl2 (2.8 mL), and adding thionyl chloride (309 μL, 4.2 mmol) and 3 μL DMF (0.04 mmol). The reaction mixture was stirred for 5 hours and concentrated in vacuo, repeatedly dissolving in CH2Cl2 (3××) to provide FMOC-Leu*-Cl as a colorless oil (146 mg, 92%): IR (cm−1) −1804, 1720, 1715. FMOC-Phe*-Cl was similarly prepared.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06608026B1 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-6034ad8ef5ff4f3dae7ffeb683697265 |
| Source note | uspto-grants-2003_08 |