Diethyl Ether → HCID 131724029, compound

HRID 396116Notes

Reaction equation

HRID 396116 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[CH:17]([S:19]([CH:22]=[CH2:23])(=[O:21])=[O:20])=[CH2:18].CC[O:26]CC>>[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[S:19]([C:22]1[CH:23]=[CH:5][C:4]([CH3:6])=[CH:3][CH:2]=1)([OH:20])(=[O:21])=[O:26].[CH:17]([S:19]([CH:22]=[CH2:23])(=[O:21])=[O:20])=[CH2:18]

Participants

3

Reactant 2

HCID 3283Diethyl EtherHCID 131724030HCID 131724030, compound

Product 1

HCID 131724029HCID 131724029, compound

Procedure

An Et2O solution of anhydrous p-Tosic acid (3 equiv.) was added to dry oil of Boc-Leu-vinylsulfone (1 equiv.) and stirred at room temperature overnight. The product formed a white precipitate which was recovered by centrifugation.

Workup

  1. customThe product formed a white precipitate which
  2. customwas recovered by centrifugation

Sources & evidence

ORD record
ord-e1ec861a304947cd8b296bcb5d2e0a1b
Source dataset
uspto-grants-2003_08
Patent number
US06608030B1

Reaction notes

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