HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(Benzyloxy)-2-nitrobenzaldehyde → 1-[5-(Benzyloxy)-2-nitrophenyl]-2-buten-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(Benzyloxy)-2-nitrobenzaldehyde | HCID 3849835 | — |
| Reactant | HCID 178456053 | HCID 178456053 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-[5-(Benzyloxy)-2-nitrophenyl]-2-buten-1-ol | HCID 70000600 | 56% |
Reaction Steps
Analogously to the procedure of example II, starting from 3.00 g (11.66 mmol) of 5-benzyloxy-2-nitrobenzaldehyde in 60 ml of THF and 37.8 ml (18.66 mmol) of a 0.5 M 1-propenylmagnesium bromide solution in THF at −78° C., 1.95 g (56%) of 1-[5-(benzyloxy)-2-nitrophenyl]-2-buten-1-ol are obtained as an E/Z mixture.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06608049B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-fc127e8d8a3042f9b4bb130d9f7a5698 |
| Source note | uspto-grants-2003_08 |